What is baricitinib?

Baricitinib, also known as Olumiant, is used to treatrheumatoid arthritis. It's a type of drug known as a Janus kinase JAK inhibitor. It works by blocking the action of Janus kinase enzymes, which are involved in the inflammation that causes the symptoms of rheumatoid arthritis.

stif Baricitinib可以缓解疼痛的症状fness and swelling in your joints and slow the joint damage that rheumatoid arthritis can cause. Most people who benefit from this treatment will notice some improvement within the first 12 weeks of treatment.




Baricitinib is not recommended if you're pregnant, planning to become pregnant or breastfeeding. Your doctor may decide not to prescribe baricitinib if you've had or have any of the following:

  • an active infection
  • 重复或严重的先前感染
  • 带状疱疹
  • disease of the lungs, liver or kidneys
  • 心脏问题,高血压,高胆固醇或血凝块(深静脉血栓形成或肺栓塞)
  • 癌症
  • very low white or red blood cell count.

You'll have blood tests before treatment starts to assess your condition and to check whether the drug is suitable for you. You'll also need these tests while you're taking baricitinib.

Your doctor will need to check if you’ve previously been exposed to tuberculosis (TB). Even if you don’t have symptoms, the bacteria that cause TB may still be present in the body, and you may need a course of treatment to deal with this before starting baricitinib.

If you've previously had hepatitis you may need regular checks for this as baricitinib may increase the risk of the hepatitis coming back.

When and how do I take baricitinib?


如果您错误地服用的剂量超过了建议的剂量,请立即与您的医生联系。如果您错过了剂量,请在第二天服用通常的剂量 - 不要加倍。






Because baricitinib affects your immune system, it can make you more likely to pick up infections. These are not usually serious and include throat, nose and chest infections, cold sores, urinary tract infections and stomach upsets.

Some people may have more serious infections including shingles, skin infections, known as cellulitis, and in rare cases hepatitis or tuberculosis.




If your red or white blood cell count gets too low, your treatment may be stopped until it improves.

It’s possible that baricitinib may increase the risk of blood clots, called deep vein thrombosis.

These can sometimes move to the lungs, which is called pulmonary embolism. The risk is likely to be greater if you've had blood clots before. You should seek urgent medical care if you develop painful swelling of the legs, chest pains or breathlessness.

Tips to reduce your risk of infection

  • Try to avoid close contact with people you know have an infection.
  • Wash your hands regularly and carry around a small bottle of antibacterial hand gel.
  • 定期刷牙来保持嘴巴清洁。
  • Stop smoking if you're a smoker.
  • 确保您的食物存储并准备好。
  • Try to keep your house clean and hygienic, especially the kitchen, bathrooms and toilets.


You'll probably be taking methotrexate as well as baricitinib. However, some drugs may interact with baricitinib. Check with your doctor before starting any new medicines and remember to mention you're on baricitinib if you're treated by anyone other than your usual rheumatology team.

You can carry on takingnon-steroidal anti-inflammatory drugs (NSAIDs) or painkillers,如果需要,除非您的医生另有建议。

Don't take over-the-counter or herbal medicines without discussing it first with your rheumatology team.


It's best to discuss vaccinations, including any you may need if you're planning to travel abroad, with your rheumatology team. If possible, it's best to have any vaccinations you may need before starting baricitinib.


The Zostavax shingles vaccine is a live vaccine and isn’t recommended for people who are on baricitinib. However, a non-live shingles vaccine (Shingrix) is available so you may be able to have this instead.


Having an operation

If you're thinking about having surgery, talk this over with your healthcare team. They may advise you to stop baricitinib for a time before and after surgery.



Government guidelines say both men and women should have no more than 14 units of alcohol a week. You should try to spread these out evenly throughout the course of the week. This is equivalent to about six glasses of wine or six pints of beer.


Fertility, pregnancy and breastfeeding


It's not yet known whether baricitinib passes into breast milk so you should talk to your rheumatology team if you’re thinking of breastfeeding.

There's no information currently available about whether baricitinib might affect male or female fertility.