Baricitinib

Baricitinib, also known as Olumiant, is used to treatrheumatoid arthritis. It's a type of drug known as a Janus kinase JAK inhibitor. It works by blocking the action of Janus kinase enzymes, which are involved in the inflammation that causes the symptoms of rheumatoid arthritis.

stif Baricitinib可以缓解疼痛的症状fness and swelling in your joints and slow the joint damage that rheumatoid arthritis can cause. Most people who benefit from this treatment will notice some improvement within the first 12 weeks of treatment.

Bariticinib适合我吗？

可以由类风湿关节炎的成年人的风湿病学家开处方。它可以单独使用，也可以与其他疾病改良的抗风湿药（DMARD）一起使用，例如甲氨蝶呤。

如果您没有尝试其他适合您的病情的治疗方法，则不会给您带来Bariticinib。

Baricitinib is not recommended if you're pregnant, planning to become pregnant or breastfeeding. Your doctor may decide not to prescribe baricitinib if you've had or have any of the following:

• an active infection
• 重复或严重的先前感染
• 带状疱疹
• disease of the lungs, liver or kidneys
• 心脏问题，高血压，高胆固醇或血凝块（深静脉血栓形成或肺栓塞）
• 癌症
• very low white or red blood cell count.

You'll have blood tests before treatment starts to assess your condition and to check whether the drug is suitable for you. You'll also need these tests while you're taking baricitinib.

Your doctor will need to check if you’ve previously been exposed to tuberculosis (TB). Even if you don’t have symptoms, the bacteria that cause TB may still be present in the body, and you may need a course of treatment to deal with this before starting baricitinib.

If you've previously had hepatitis you may need regular checks for this as baricitinib may increase the risk of the hepatitis coming back.

Bariticinib每天被视为平板电脑。在某些情况下，例如，如果您超过75岁，或者如果您已经反复感染，您的医生可能会决定减少标准剂量。

如果您错误地服用的剂量超过了建议的剂量，请立即与您的医生联系。如果您错过了剂量，请在第二天服用通常的剂量 - 不要加倍。

如果您在六个月后尚未注意到症状的任何改善，您的医生可能会决定停止Bariticinib治疗。

因为这是一种长期治疗方法，所以重要的是要继续服用Bariticinib，除非您有严重的副作用，即使它一开始似乎没有工作。即使症状改善，您仍然应该继续服用它，以帮助控制状况。

像任何药物一样，巴甲基尼有时会引起副作用，但许多人不会有任何问题。您应该与风湿病团队谈谈您的任何副作用。

在开始Bariticinib后的前两周，您可能会感到恶心，被称为恶心，但这通常会随着时间而改善。

Because baricitinib affects your immune system, it can make you more likely to pick up infections. These are not usually serious and include throat, nose and chest infections, cold sores, urinary tract infections and stomach upsets.

Some people may have more serious infections including shingles, skin infections, known as cellulitis, and in rare cases hepatitis or tuberculosis.

如果您产生任何感染迹象，例如喉咙痛或持续性咳嗽，发烧或发冷或任何其他有关您的新症状，请立即告诉您的医生或风湿病学护士。如果这些症状中的任何一个很严重，您应该停止服用Bariticinib，并立即去看医生。

如果您开发水痘或带状疱疹，或者与有水痘或带状疱疹的人接触，也应该去看医生。您可能需要治疗，并且可能需要停止服用Bariticinib，直到您改善为止。

一些服用巴甲比的人可能会减少白细胞计数，升高胆固醇或升高的肝酶。这些问题通常很温和，但是您的风湿病团队将在您服用Baricitinib作为预防措施时定期进行血液检查。

If your red or white blood cell count gets too low, your treatment may be stopped until it improves.

It’s possible that baricitinib may increase the risk of blood clots, called deep vein thrombosis.

These can sometimes move to the lungs, which is called pulmonary embolism. The risk is likely to be greater if you've had blood clots before. You should seek urgent medical care if you develop painful swelling of the legs, chest pains or breathlessness.

Tips to reduce your risk of infection

• Try to avoid close contact with people you know have an infection.
• Wash your hands regularly and carry around a small bottle of antibacterial hand gel.
• 定期刷牙来保持嘴巴清洁。
• Stop smoking if you're a smoker.
• 确保您的食物存储并准备好。
• Try to keep your house clean and hygienic, especially the kitchen, bathrooms and toilets.

You'll probably be taking methotrexate as well as baricitinib. However, some drugs may interact with baricitinib. Check with your doctor before starting any new medicines and remember to mention you're on baricitinib if you're treated by anyone other than your usual rheumatology team.

You can carry on takingnon-steroidal anti-inflammatory drugs (NSAIDs) or painkillers，如果需要，除非您的医生另有建议。

Don't take over-the-counter or herbal medicines without discussing it first with your rheumatology team.

It's best to discuss vaccinations, including any you may need if you're planning to travel abroad, with your rheumatology team. If possible, it's best to have any vaccinations you may need before starting baricitinib.

通常建议您使用Baricitinib的人避免使用实时疫苗。这些包括麻疹，腮腺炎和风疹（MMR），结核病（BCG）和黄热病。

The Zostavax shingles vaccine is a live vaccine and isn’t recommended for people who are on baricitinib. However, a non-live shingles vaccine (Shingrix) is available so you may be able to have this instead.

有助于预防肺炎的肺炎球菌疫苗，除鼻流感疫苗外，每年的流感疫苗都很好，通常建议使用。

If you're thinking about having surgery, talk this over with your healthcare team. They may advise you to stop baricitinib for a time before and after surgery.

巴比略尼和酒精之间没有已知的相互作用，因此，如果您要服用这种药物，可以喝一杯。

Government guidelines say both men and women should have no more than 14 units of alcohol a week. You should try to spread these out evenly throughout the course of the week. This is equivalent to about six glasses of wine or six pints of beer.

您可以在www.drinkaware.co.uk.

目前，我们对Bariticinib在怀孕中的影响一无所知。为了安全起见，如果您怀孕或计划怀孕，不建议使用Bariticinib。如果您可以怀孕，则应在接受Bariticinib治疗时使用有效的避孕药，并在停止治疗后至少一周。

It's not yet known whether baricitinib passes into breast milk so you should talk to your rheumatology team if you’re thinking of breastfeeding.

There's no information currently available about whether baricitinib might affect male or female fertility.