febosostat

什么是febosostat,如何使用?

定期服用,febosostat可以防止关节损坏,停止攻击gout并减少影响皮肤的痛风肿块的大小。

人体自然会产生一种称为尿酸的物质,该物质通常溶于血液,并在尿液中流失。在痛风中,血液无法溶解所有尿酸盐,因此在关节内外形成固体晶体,从而引起炎症和疼痛。

Febosostat通过阻止尿酸盐的生产来起作用。这使尿酸盐的水平足以使晶体长期开始溶解并防止痛风的攻击。

在开始2月之前,大多数人会尝试另一种名为别嘌醇。两种药物都以类似的方式起作用,但是只有当您的医生怀疑您可能对别嘌醇反应不良或您的副作用时,才使用Febosostat。

febosostatis also known by the brand name Adenuric.

在开始febosostat之前要知道的事情

Urate lowering drugs, like febuxostat, are very effective for the long-term treatment ofgout。如果:

  • 您正在反复对痛风的攻击
  • your joints or kidneys have been damaged by attacks of gout
  • 您有痛风的肿块,称为Tophi。

但是,Febosostat可能并不适合所有人。您的医生可能决定不开处方Febosostat,如果

  • you’ve had a severe heart condition
  • 你有严重的肾脏或肝脏问题
  • 您有甲状腺问题。

Your doctor will arrange for you to have a blood test before you start treatment to check your urate levels, kidneys and liver.

febosostattablets contain lactose, so tell your doctor if you’re lactose intolerant.

怎么样?

您的医生可能建议您在攻击后不要开始服用Febosostatgout已经完全解决了。如果不可能,则可能在痛风处于温和阶段时开始。

它的s important to be aware that as the crystals begin dissolving they can become dislodged. Because of this, you may actually have more attacks of gout during the first few weeks of treatment.

这并不意味着药物无法正常工作,所以不要停止服用Febosostat,而是像通常一样对待攻击。

一旦您的尿酸盐水平得到充分降低,痛风通常会在一年内停止。

每天有或没有食物,每天以平板电脑的形式服用febosostat。片剂应用水吞咽。您的医生会建议您正确的剂量。通常,您每天从80毫克开始,但是如果您的血液尿酸盐水平不足以使晶体溶解,您的医生会定期进行血液检查,并可能每天增加120毫克。

一旦您的尿酸盐水平稳定并且在目标范围内,您将需要每年的血液检查以检查尿酸盐水平保持不变。

febosostatis a long-term treatment. So, it’s important to keep taking it even:

  • 如果起初似乎没有工作
  • 如果您首次开始febosostat时对痛风有更多攻击
  • 当您停止对痛风攻击时,否则尿酸盐水平可能会再次开始积累,并且您的症状可能会恢复。

对其他治疗的影响

您的医生经常建议您采取一些措施,以防止在Febosostat开始后的头六个月或增加剂量后,以防止痛风的袭击。这通常是非甾体类抗炎药(NSAID)布洛芬; colchicine or a low dose of steroids.

However, some drugs interact with febuxostat, so you should discuss any new medication with your doctor before starting it, and you should always tell anyone else treating you that you’re taking febuxostat.

以下药物与Febosostat相互作用,通常不应与Febosostat一起服用:

  • Azathioprine(Aza-thy-o-Preen) - 用于治疗免疫条件,例如类风湿关节炎
  • 胃嘌呤(Mer-kap-toh-pyoo-reen) - 用于治疗癌症和免疫疾病。
  • Didanosine(dy-da-no-seen) - 有时用于艾滋病毒的治疗。

Possible risks and side effects

Febosostat最常见的副作用是在治疗早期阶段的痛风攻击增加。但是,如果您确实有攻击gout, don’t stop taking febuxostat. Treat the attack as you would normally.

Most people do not experience other side effects. For those who do, they aren’t usually serious. However, if you have severe side effects, or are concerned about your symptoms, contact one of the healthcare professionals in charge of your care.

一些最常见的副作用可能包括:

  • diarrhoea
  • headaches
  • 皮疹
  • 感到恶心(恶心)
  • 肝脏检查结果异常
  • 液体的积聚,通常是小腿和脚踝。

如果您开始2月,面部肿胀或发烧,尤其是在第一个月,您应该立即寻求医疗建议。您还应该告诉医生您是否出现任何新症状,或者还有其他与您有关的东西。

If you’re unable to continue taking febuxostat, and you’ve already tried别嘌醇unsuccessfully, your doctor may suggest a drug such as benzbromarone or sulfinpyrazone. These drugs reduce urate levels by increasing the amount of urate passed in the urine.

疫苗接种

你可以在febuxostat接种疫苗。

酒精

酒精与Febosostat并未显着相互作用,但确实会增加血液中尿酸盐的水平。因此,它可以使您更容易受到痛风的攻击。

Government guidelines say both men and women should have no more than 14 units of alcohol a week. This is equivalent to about six glasses of wine or six pints of beer. You can find out more about units of alcohol atwww.drinkaware.co.uk

您的医生可能会建议下限作为您的一般治疗计划的一部分,以降低尿酸盐水平。

生育能力,怀孕和母乳喂养

它的s not known what effect febuxostat can have on your baby, so you shouldn’t take it if you’re pregnant or breastfeeding.

If you’re planning a family or become pregnant while taking febuxostat you should discuss this with your doctor.

The effects of febuxostat on fertility are not currently known, but it’s unlikely to be harmful.