Secukinumab

Secukinumab is a type of drug known as a biological therapy. Your doctor may give it to you if you have:

• psoriatic arthritis
• 强直性脊柱炎。

It can also be used to treat psoriasis if it’s severe and other treatments haven’t worked.

在某些情况下，包括银屑病关节炎和强直性脊柱炎，蛋白质IL-17A会导致炎症，疼痛和对身体部分的损害，例如关节。secukinumab通过阻止该蛋白质的作用，减少炎症及其可能引起的问题，例如关节疼痛和僵硬，起作用。

这是一种长期治疗。根据您的状况，在您开始看到好处之前，可能需要三个星期至一年的时间。

有关于何时可以使用secukinumab的准则。它取决于您的条件。

Secukinumab won’t be started if:

• 您的病情不活跃
• 您没有先尝试其他治疗方法
• 你有感染。

Before you're given secukinumab, doctors sometimes use a scoring system to assess how many of your joints are painful or swollen, and how it makes you feel. This helps them work out how active your arthritis is.

您还需要进行血液检查和胸部X射线治疗，以查看Secukinumab是否适合您。

Your doctor may also decide not to prescribe secukinumab if:

• 您过去曾重复或严重感染
• 你有一个炎症性肠病,如Crohn’s disease or ulcerative colitis
• you’re pregnant, planning to becomepregnant，或母乳喂养
• 您正在接受牛皮癣的紫外线治疗，也称为光疗。

If secukinumab isn’t suitable, your doctor will discuss other treatment options with you.

医生会检查你是否有tuberculosis (TB). Even if you don’t have symptoms, the bacteria that causes TB may still be present in your body. So, you may need treatment for this before starting secukinumab.

Your doctor might also check if you’ve had hepatitis before. If you have, you may be offered a treatment to reduce the risk of the hepatitis restarting.

您的医生可能会评估您的艾滋病毒感染风险，并可能建议进行测试。如果您患有艾滋病毒，您的医生可能希望确保在开始Secukinumab之前得到很好的控制。

Secukinumab作为皮肤下的注射。这被称为皮下注射。

For the first four weeks of taking secukinumab, you will need to have one injection a week. After that, you will only need to take secukinumab once a month.

Secukinumab is available in a pre-filled syringe or pen so that you, your partner, or another family member can learn to give you these injections at home.

如果您错过剂量或太早服用，请问您rheumatology team有关何时服用下一次剂量的建议。

如果您有乳胶过敏，则应向您的医生提及。一些预填充注射器上的针盖可能包含乳胶，并可能引起反应。

Because it’s a long-term treatment, it’s important to keep taking secukinumab:

• 即使起初似乎没有工作
• 即使您的症状开始改善。

But if you have severe side effects or symptoms of an infection, tell your healthcare team. They may recommend that you delay or stop your treatment.

像所有药物一样，secukinumab有时会引起副作用。一些常见的副作用包括：

• a sore throat or a dry cough
• 疲劳
• 流鼻涕
• feeling sick
• diarrhoea.

有些人可能在注射部位有皮肤反应。这通常是温和的，症状包括发红，皮疹，肿胀，瘙痒或瘀伤。

Very rarely, some people may have a more severe allergic reaction. The symptoms of an allergic reaction include sudden swelling, a rash or breathlessness. If you develop these symptoms during or soon after a dose of secukinumab, you should get medical advice immediately.

由于secukinumab会影响您的免疫系统，因此您可能更有可能接收感染。

如果您有任何感染症状，或者不确定，请立即与风湿病团队联系。他们可能建议您将下一个剂量推迟到更好。感染的一些症状包括：

• a fever
• 感觉累了
• shortness of breath
• a constant cough
• diarrhoea
• 撒尿时燃烧。

You should also speak to your healthcare team if you develop chickenpox or shingles, or come into contact with someone who has chickenpox or shingles.

如果您要服用secukinumab，这些感染可能会很严重。您可能需要抗病毒治疗，并且您的secukinumab治疗可能会停止，直到您改善为止。

减少感染风险的提示

• 尽量避免与您认识的感染者密切接触。
• 定期洗手，携带一小瓶抗菌手凝胶。
• Keep your mouth clean by brushing your teeth regularly.
• Stop smoking if you’re a smoker.
• Make sure your food is stored and prepared properly.
• 尝试保持房屋清洁和卫生，尤其是厨房，浴室和厕所。

It’s recommended that you carry a biological therapy alert card so anyone treating you will know that you’re on secukinumab. Ask yourrheumatology team用于卡。

You may be taking other drugs as well as secukinumab. Check with your doctor before starting any new medicines. Remember to mention you’re on secukinumab if you’re treated by anyone other than your usual rheumatology team.

Don’t usecomplementary treatments，例如草药疗法，而无需与您的医生或药剂师讨论。他们中的一些人可以与secukinumab反应。

疫苗接种

It’s best to discuss vaccinations with your healthcare team before starting secukinumab.

It’s usually recommended that people on secukinumab avoid live vaccines such as measles, mumps and rubella (MMR), chickenpox and yellow fever. But sometimes a live vaccine may be necessary, so you should discuss this with your rheumatology team.

If you’ve never had chickenpox, it’s good to get a vaccination against it before starting secukinumab. But discuss this with yourrheumatology team第一的。

在开始服用Secukinumab之前，让任何家庭或家庭成员接种水痘接种也是一个好主意。

If you’re offered shingles vaccination (Zostavax), it’s best to have this before starting secukinumab. The Zostavax shingles vaccine is a live vaccine and isn’t recommended for people who are on secukinumab. But a non-live shingles vaccine (Shingrix) is available so you may be able to have this instead.

It’s recommended that you have the vaccination against COVID-19. It’s also recommended that you have the pneumonia vaccine and your yearly flu vaccine injection while taking secukinumab. These vaccines are not live, so you are able to have them whilst on biologic therapy.

有操作

If you’re going to have an operation or dental surgery, you should talk this over with your doctor or surgeon.

根据手术的类型，您的医生可能建议您在手术前后停止Secukinumab一段时间。

这是因为secukinumab会影响您的免疫系统。因此，手术后您可能会增加感染的风险。

There’s no need to avoid alcohol while taking secukinumab.

指南指出，成年人每周不应超过14个单位，并且应该在一周中将其散布。在某些情况下，您的医生可能会建议下限

Secukinumab currently isn’t recommended if you’repregnant。

由于Secukinumab是一种相对较新的药物，我们尚不知道它可能会影响怀孕或未出生的婴儿。告诉你的rheumatology teamimmediately if you become pregnant whilst taking secukinumab.

如果您是育龄的女性，那么在服用secukinumab时使用避孕是一个好主意，在完成治疗后五个月。

一些准则说，要父亲的男人可以安全使用secukinumab。但是研究处于早期阶段。如果您担心或想了解更多，请与您的医疗团队交谈。

我们还不知道Secukinumab是否可以进入母乳，因此当前的建议不是在服用这种药物时母乳喂养。