What is etanercept and how is it used?
Inrheumatoid arthritis和some other inflammatory conditions, too much of a protein called TNF is produced by the immune system. This causes inflammation, pain and damage to your joints. Anti-TNF drugs, such as etanercept, block TNF and reduce inflammation.
Etanerceptisn’t a painkiller, but it can reduce the effects of your condition. Your symptoms should start to improve 2–12 weeks after you start taking it.
Etanerceptcan be prescribed by aconsultant rheumatologist为了：
- rheumatoid arthritis (roo-ma-toy-d arth-ri-tus)
- 银屑病关节炎(saw-ree-at-ik arth-ri-tus)
- ankylosing spondylitis（an-kee-low-sing spon-dee-lie-tus）
- 幼年特发性关节炎（Joo-Vuh-nahyl ID-EE-UH-PATH-IK ARTH-RI-TUS（JIA）。
Etanerceptis taken once or twice a week as an injection under the skin, known as a subcutaneous injection.
If you forget to take your etanercept contact yourrheumatology team。They’ll be able to advise you on when to take it next.
Etanerceptmay not work right away, so it’s important to continue taking it even if it doesn’t seem to be working. You should also continue taking it as prescribed when your symptoms improve and you start to feel better, as this will keep your condition under control.
Etanerceptis a very effective drug for many people with arthritis. But it’s not suitable for everyone.
Before you’re prescribed etanercept, doctors sometimes use a scoring system to work out how active your arthritis is. The system used depends on what condition you have, but you’ll probably be asked how well you feel on a scale of 1 to 10 and your doctor will make a note of how many of your joints feel tender and swollen.
你还需要血液检测出活性e your condition is and to check whether the drug is suitable for you.
你的doctor might not prescribe etanercept if:
- you have severe heart problems
- you, or a close family member, have multiple sclerosis (MS)
- you have lung problems.
This drug should be used with caution if you have infections that repeatedly come and go.
Before starting etanercept, you’ll have a chest x-ray and tests to check if you’ve ever been exposed to tuberculosis (TB). If you have, you may need treatment for TB before you can start taking it.
- a blocked or runny nose
- feeling sick or vomiting
- a mild fever
In rare cases, people experience allergic reactions. This could be in the form of swelling, a rash or you may feel short of breath. If you do develop these symptoms, or any other severe symptoms, during or soon after a dose of etanercept you should seek medical advice straight away.
Because etanercept affects the immune system, it can make you more likely to develop the symptoms of a cold or to pick up infections. Tell your doctor orrheumatology nursestraight away if you develop any of the following symptoms:
- a cough that won’t go away
- unexpected weight loss
还要让他们知道您是否注意到任何无法解释的瘀伤或出血。你的rheumatology teammight advise you to pause or stop treatment.
Tips to reduce your risk of infection
- Try to avoid close contact with people you know have an infection.
- Wash your hands regularly and carry around a small bottle of antibacterial hand gel.
- Make sure your food is stored and prepared properly.
- Try to keep your house clean and hygienic, especially the kitchen, bathrooms and toilets.
如果您要服用Etanercept，您可能会服用甲氨蝶呤as well. Check with your doctor before starting any new medications.
Remember to mention you’re on etanercept if you’re treated by anyone other than your usualrheumatology team，因为它不会从GP中出现在您的重复处方列表中。
It’s recommended that you carry a biological therapy alert card, so anyone treating you will know that you’re on etanercept.
Don’t take over-the-counter preparations or herbal remedies without talking to your healthcare team or a pharmacist, as some of them may react badly with etanercept.
The pneumonia (new-mow-nee-uh) vaccine and yearly flu vaccines don’t affect etanercept and are perfectly safe to have while you’re taking it. It’s very important to have these to reduce your risk of infection.
It's usually recommended that you avoid having live vaccines such as MMR (measles, mumps and rubella) or yellow fever and chickenpox.
如果您从未有水痘，那么在开始Etanercept之前，可以接种疫苗。但是与您讨论rheumatology teamfirst. It’s also a good idea to get any family or household members vaccinated against chickenpox before you start taking etanercept.
The Zostavax shingles vaccine is a live vaccine and isn’t recommended for people who are on etanercept. However, a non-live shingles vaccine (Shingrix) is available so you may be able to have this instead.
Having an operation
Talk this over with your rheumatology team. It’s likely you’ll be advised to stop etanercept for a couple of weeks before and after surgery.
Government guidelines say both men and women should have no more than 14 units of alcohol a week. This is equivalent to about six glasses of wine or six pints of beer.
You can find out more about units of alcohol atwww.drinkaware.co.uk。
If you’re planning to try for a baby, if you become pregnant, or if you’re thinking of breastfeeding, we suggest you discuss your medications with your rheumatologist.
If this is the case, your baby shouldn’t have any live vaccines until they’re at least seven months old. For more information talk to your rheumatology team and your child’s doctor, as some vaccines will still be safe for them to have.
There’s only limited information about the use of etanercept while breastfeeding, but there’s no research to show that it’s harmful.
Current guidelines state that men trying to father a baby should be ok to continue taking etanercept or甲氨蝶呤。If in doubt discuss this with your rheumatologist first.
Women who are taking methotrexate as well as etanercept should stop taking methotrexate at least three months before trying for a baby. Methotrexate should not be restarted until after you’ve finished breastfeeding.