golimoumab

golimoumabis a type of drug known as a biological therapy. It's also known by the brand name Simponi.

在类风湿关节炎和其他一些炎症条件，过多的一种称为肿瘤坏死因子（TNF）的蛋白质是由免疫系统产生的。这会导致关节炎症，疼痛和损害。抗TNF药物，例如Golimumab，阻断TNF并减少炎症。

golimoumabisn't a painkiller, but it can reduce the effects of your condition. Your symptoms should start to improve after about 8–12 weeks.

golimoumabcan be prescribed by a顾问风湿病学家for:

• 类风湿关节炎（Roo-Ma-Toy-Darth-Ri-tus）
• psoriatic arthritis（Saw-re-at-Ik arth-ri-tus）
• 轴向脊椎关节炎（Axe-EE-EE-Allspon-Dee-low-arth-Ri-tus），包括强直性脊柱炎（an-kee-low-sing spon-dee-lie-tus）
• 幼年特发性关节炎（joo-vuh-nahyl id-ee-oh-path-ik arth-ri-tus）。

golimoumab通常与methotrexate。

For rheumatoid arthritis and psoriatic arthritis, biological therapies such as golimumab, won't usually be prescribed unless you've tried at least two disease-modifying anti-rheumatic drugs (DMARDs). These include drugs like methotrexate,sulfasalazineandleflunomide。

在axial spondyloarthritis, biological therapies are usually prescribed after someone has unsuccessfully tried two非甾体类抗炎药（NSAIDS）。

对于许多关节炎患者来说，Golimoumab是一种非常有效的药物。但这并不适合所有人。

在您开处方Golimoumab之前，医生有时会使用评分系统来弄清您的关节炎的活跃程度。所使用的系统取决于您的状况，但是您可能会询问您在1到10的尺度上感觉如何，您的医生会记下多少关节感到嫩和肿胀。

在开始治疗之前，您还需要进行血液检查，以确定病情的活跃程度，并检查该药物是否适合您。

如果以下情况，您的医生可能不会开golimoumab。

• 您怀孕或母乳喂养
• 你有艾滋病毒
• 您有多发性硬化症（MS）
• 你患有癌症
• you've had a heart condition
• 你有肺部问题。

如果您有反复来来去去的感染，则应谨慎使用该药物。

Before starting golimumab, you’ll have a chest X-ray and a test to check whether you've ever been exposed to tuberculosis (TB). If you have, you may need treatment for TB before you can start taking it.

You’ll also be checked for previous hepatitis B or C infections as golimumab may increase the risk of these conditions starting up again.

每月通过在皮肤下注射一次，通常会进入大腿，腹部或上臂。这被称为皮下注射。它是注射器笔或注射器，您或家人可以在家中学习使用。您应该保持戈尔木单抗的冷藏。

如果您忘记接受Golimumab，请与您的风湿病团队。他们将能够为您提供下一个何时服用的建议。

Golimumab可能不会立即起作用，因此，即使它似乎不起作用，继续进行它也很重要。当您的症状改善并开始感觉更好时，您还应该继续按照规定的规定进行服用，因为这将使您的病情受到控制。

大多数患者在服用golimoumab时会进行定期的血液检查。

Most people don't have any side effects, and for those who do, they aren't usually serious. However, if you do have severe side effects, or are concerned about your symptoms, contact one of the healthcare professionals in charge of your care.

Some of the most common side effects include:

• indigestion
• 肌肉无力
• 头晕
• headaches
• 高血压

有些人可能会在注射时产生反应，例如疼痛，发红或肿胀。这些反应应在经过一个月的治疗后停止。定期更改注射点将减少发生这种情况的机会。

在极少数情况下，人们会经历过敏反应。这可能是肿胀或皮疹，或者您可能会感到呼吸。如果您确实在服用golimoumab剂量后或不久后会出现这些或任何其他严重症状，请立即寻求医疗建议。

Because golimumab affects your immune system, you may be more likely to develop the symptoms of a cold or to pick up infections. You should tell your doctor or风湿病护士如果您出现以下任何症状，请立即离开：

• 咳嗽不会消失
• 意外的体重减轻
• 发热。

另外，让他们知道您是否注意到任何无法解释的瘀伤或出血。您的风湿病团队可能建议您暂停或停止治疗。

You should contact your rheumatology team if you get chickenpox or shingles, or come into contact with someone who has them and you have never had chickenpox before. These illnesses can be worse than usual if you're on golimumab. You may need treatment for them and your golimumab may be stopped until you're better.

Anti-TNF drugs have been associated with some types of skin cancer. However, the link between the two is unclear. Skin cancers can often be treated successfully when diagnosed early. To be on the safe side, make sure to wear sunscreen and regularly check your skin for any new spots or changes to your freckles or moles.

戈尔木单抗很少会导致称为药物诱导的狼疮的疾病。症状包括皮疹，发烧和增加关节疼痛。如果您有任何这些症状，请告诉您的风湿病团队。这种情况通常会清除，如果停止了Golimoumab。

减少感染风险的提示

• 尽量避免与您认识的感染者密切接触。
• 定期洗手，携带一小瓶抗菌手凝胶。
• Keep your mouth clean by brushing your teeth regularly.
• 如果您是吸烟者，请停止吸烟。
• 确保您的食物存储并准备好。
• 尝试保持房屋清洁和卫生，尤其是厨房，浴室和厕所。

建议您携带一张生物疗法警报卡，以便任何对待您的人都知道您在Golimumab上。向您的风湿病团队咨询卡。

If you're taking golimumab, you’ll probably be taking methotrexate as well.

在开始任何新药物之前，请先检查医生。请记住，如果您受到通常的风湿病团队以外的任何人的治疗，请提及您在Golimumab上，因为它不会从GP中重复处方列表中出现。

You can carry on taking a non-steroidal anti-inflammatory drug (NSAID), such as布洛芬， 要么止痛药，例如如果需要的话，例如扑热息痛，除非您的医生另有建议。

Don't take over-the-counter or herbal remedies without talking to your healthcare team or a pharmacist, as some of them may react badly with golimumab.

疫苗接种

建议您对COVID-19进行疫苗接种。建议您在服用Golimumab时接受肺炎（New-Moh-Nee-UH）疫苗和年度流感疫苗。这些疫苗不是活的，因此您可以安全地使用它们。

It's usually recommended that people on golimumab avoid live vaccines such as measles, mumps and rubella (MMR), chickenpox and yellow fever. But sometimes a live vaccine may be necessary, so you should discuss this with your rheumatology team.

If you've never had chickenpox, it’s good to get a vaccination against it before starting golimumab. But discuss this with your rheumatology team first.

It’s also a good idea to get any family or household members vaccinated against chickenpox before you start taking golimumab.

Zostavax带状疱疹疫苗是一种现场疫苗，不建议使用Golimabab的人。但是，可以使用非叶片带疫苗（Shingrix），因此您可以使用此疫苗。

If you’re unsure about whether you should be having a vaccine, make sure to have a chat with your rheumatology team.

有操作

与您的风湿病团队讨论。可能会建议您在手术前大约五个星期停止Golimoumab。

戈尔木单抗和酒精之间没有已知的相互作用，因此，如果您要服用这种药物，可以喝一杯。

Government guidelines say both men and women should have no more than 14 units of alcohol a week. This is equivalent to about six glasses of wine or six pints of beer. It's best to spread the 14 units out over the course of the week and to have at least one alcohol-free day.

您可以在www.drinkaware.co.uk。

If you're planning to try for a baby, if you become pregnant, or if you're thinking of breastfeeding, we suggest you discuss your medications with your rheumatologist.

当前的准则说，大多数抗TNF药物都可以在怀孕的前三个月服用。但是，由于这种药物相对较新，因此关于其在怀孕期间的影响的信息很少。您应该讨论是否应该继续与医生一起服用Golimumab。

If you were to take it throughout pregnancy, particularly in the last three months, then your baby shouldn't have any live vaccines until they are at least six months old. For more information, talk to your rheumatology team and your child's doctor.

最近的指南指出，您可以在服用Golimoumab时母乳喂养，因为人们认为只有很少的药物进入母乳。

尽管没有太多证据，但指南还建议男人如果试图和伴侣生孩子，可以服用戈尔木马。有关更多信息，请与您的风湿病学家交谈。