柳叶刀》文章甲氨蝶呤和辉瑞/ Biontech疫苗研究

jamieA

医学杂志《柳叶刀》发表了一篇关于服用甲氨蝶呤的作用对辉瑞疫苗的功效。它是基于一项小型研究在纽约和德国,但似乎表明,甲氨蝶呤用户降低应对辉瑞疫苗- 62%而不是90%。

https://www.thelancet.com/journals/lanrhe/article/piis2665 - 9913(21) 00212 - 5 /全文

stickywicket

谢谢,杰米。我高兴地看到,英国终于醒来。当然,到目前为止所有的研究必然是小但是美国似乎更机灵。这是我读过的最全面的东西,不可否认在国家地理杂志,但它通常是一个可靠的来源和研究它引用真实的来源。

https://www.nationalgeographic.com/science/article/the-complex-situation-for-immunocompromised-people-and-covid-19-vaccines

有趣的是,他们似乎也觉得甲氨蝶呤的困难比生物制剂,除了利妥昔单抗。我medicalese不理解所有的理由和原因,但我能理解足以感激我在苏格兰这并不是吗?——把警告,口罩,风

在过去的半小时,我刚刚有一个回复的邮件我发送给议员两周前再保险信息共享,这样其他人就会意识到,我们中的许多人并不安全,尽管疫苗。他建议我接种疫苗(? ? ?我在1月下旬和3月),会有一个英国研究在今年晚些时候出版一些结果。

Stephd

我给国家地理的文章我的风湿病学护士发现它很有趣。据我了解还没有临床研究疫苗的功效,除了我们已经排除研究所以不倾斜的结果。我已经要求医生和医院如果我能有一个抗体测试之前,所有Covid限制被取消建立如果我有任何抗体但没有运气。有人有一个抗体测试吗?我想确认只是加强下周一我的立场没有任何改变,将继续使用面具,保持社会距离的人。我现在比之前更加焦虑。非常可怕的Covid数字飙升。

由于篮

jamieA

I sent the national geographic article to my Rheumatology nurse who found it very interesting. As far as I understand there is no clinical study yet on the efficacy of the vaccine for us except that we have been left out of studies so not to skew the results for the general population. I have asked GP and hospital if I could have an antibody test ahead of all Covid restrictions being lifted to establish if I have any antibodies at all but no luck. Has anyone had an antibody test? I would like it confirmed just to reinforce my stance on not changing anything next Monday and will continue to use a mask and keep socially distant from people. I am more anxious now than I was before. Very scary with Covid numbers rocketing. <\/p>

Thanks Steph<\/p>","bodyRaw":"[{\"insert\":\"I sent the national geographic article to my Rheumatology nurse who found it very interesting. As far as I understand there is no clinical study yet on the efficacy of the vaccine for us except that we have been left out of studies so not to skew the results for the general population. I have asked GP and hospital if I could have an antibody test ahead of all Covid restrictions being lifted to establish if I have any antibodies at all but no luck. Has anyone had an antibody test? I would like it confirmed just to reinforce my stance on not changing anything next Monday and will continue to use a mask and keep socially distant from people. I am more anxious now than I was before. Very scary with Covid numbers rocketing. \\nThanks Steph \\n\"}]","format":"rich","dateInserted":"2021-07-15T17:37:35+00:00","insertUser":{"userID":115643,"name":"Stephd","url":"https:\/\/community.versusarthritis.org\/profile\/Stephd","photoUrl":"https:\/\/wc.vanillicon.com\/v2\/c5f169e14850c64356f11282e6a741b0.svg","dateLastActive":"2021-08-13T22:33:36+00:00","banned":0,"punished":0,"private":false},"displayOptions":{"showUserLabel":false,"showCompactUserInfo":true,"showDiscussionLink":false,"showPostLink":false,"showCategoryLink":false,"renderFullContent":false,"expandByDefault":false},"url":"https:\/\/community.versusarthritis.org\/discussion\/comment\/682774#Comment_682774","embedType":"quote"}"> https://community.versusarthritis.org/discussion/comment/682774 Comment_682774

篮,

《柳叶刀》杂志上的文章有点困难但了解风湿性/银屑病关节炎或牛皮癣患者服用免疫抑制剂药物。我还发现BMJ的一篇文章中覆盖相同的研究有点容易阅读。

https://www.bmj.com/company/newsroom/methotrexate-users-have-a-reduced-immune-response-to-mrna-covid-19-vaccine/

这项研究只涵盖辉瑞/ BIONTech信使核糖核酸疫苗和免疫介导的炎性疾病患者(醯亚氨)也可能是服用免疫调节药物甲氨蝶呤,肿瘤坏死因子和白介素- 17 - 23

stickywicket

@jamieA感谢。所有信息运维特别是更容易理解类型

@Stephd有一篇文章帮助热线,对这个人有一个抗原测试。4页,(我认为)疫苗在免疫抑制反应。这是由@Skap。这不是令人鼓舞,但同样的,据我了解,抗原测试并不特别可靠,没有人确切知道如何解释它们。

昨天,我们娱乐和她的丈夫在花园里碰见一个老同学,当然可以。她还对甲氨蝶呤和整个大流行已经到处闲逛。当然,接种疫苗。但是,很明显,她是受保护的或幸运的。

jamieA

@jamieA<\/a> Thanks for this. All info gratefully received especially the more easily understood type<\/p>

@Stephd<\/a> There was a post on Helplines about this by someone who had had an antigen test. It's on Page 4 and entitled (I think) vaccine response in immunosuppressed. It's by @Skap<\/a> . It's not encouraging but, equally, from what I've read, antigen tests aren't particularly reliable as no-one is quite sure how to interpret them.<\/p>

Yesterday, we entertained an old schoolfriend and her husband in the garden, of course. She's also on methotrexate and had been gallivanting all over throughout the pandemic. Vaccinated, of course. But, clearly, either she's protected or lucky.<\/p>","bodyRaw":"[{\"insert\":{\"mention\":{\"name\":\"jamieA\",\"userID\":116922}}},{\"insert\":\" Thanks for this. All info gratefully received especially the more easily understood type\\n\"},{\"insert\":{\"mention\":{\"name\":\"Stephd\",\"userID\":115643}}},{\"insert\":\" There was a post on Helplines about this by someone who had had an antigen test. It's on Page 4 and entitled (I think) vaccine response in immunosuppressed. It's by \"},{\"insert\":{\"mention\":{\"name\":\"Skap\",\"userID\":112907}}},{\"insert\":\" . It's not encouraging but, equally, from what I've read, antigen tests aren't particularly reliable as no-one is quite sure how to interpret them.\\nYesterday, we entertained an old schoolfriend and her husband in the garden, of course. She's also on methotrexate and had been gallivanting all over throughout the pandemic. Vaccinated, of course. But, clearly, either she's protected or lucky.\\n\"},{\"attributes\":{\"header\":{\"level\":1,\"ref\":\"//www.wfysxh.com/community/discussion/54650/\"}},\"insert\":\"\\n\"}]","format":"rich","dateInserted":"2021-07-16T10:19:13+00:00","insertUser":{"userID":15071,"name":"stickywicket","url":"https:\/\/community.versusarthritis.org\/profile\/stickywicket","photoUrl":"https:\/\/w9.vanillicon.com\/v2\/9fdd062ad197cafded2e18137c05f5c8.svg","dateLastActive":"2022-10-15T10:41:36+00:00","banned":0,"punished":0,"private":false},"displayOptions":{"showUserLabel":false,"showCompactUserInfo":true,"showDiscussionLink":false,"showPostLink":false,"showCategoryLink":false,"renderFullContent":false,"expandByDefault":false},"url":"https:\/\/community.versusarthritis.org\/discussion\/comment\/682810#Comment_682810","embedType":"quote"}"> https://community.versusarthritis.org/discussion/comment/682810 Comment_682810

@stickywicket

喜欢你我在苏格兰和担心的宽松政策的限制。上周我女儿的伙伴和我儿子的伙伴已经“灵感”告诉他们已经接近后检测呈阳性的人。他们都完全回到工作在过去的一个月。谢天谢地他们不活与我保持距离。他们采取了PCR测试,希望一切都好。我的妻子还在喘息支持工作所以每周PCR测试。我们现在一直在家一盒侧流试验。我很欣赏他们不是接近精确但希望总比没有好。

我在20毫克甲氨蝶呤和辉瑞疫苗,所以细节在这项研究让我诚惶诚恐。如果近4 10人,组合不产生足够的抗体抵御Covid 19然后这些机会不够好。