我们取得了什么成就？
一项由与关节炎相比的临床试验为葡萄膜炎提供了一种新的治beplay体育怎么下载疗选择，并对年轻人如何接受护理，降低视力丧失的风险和改善生活质量。
我们试图解决什么问题？
Juvenile idiopathic arthritis (JIA)是一种痛苦的炎症性关节炎，影响了英国12,000名儿童和年轻人。
JIA可能难以控制，并且可能导致其他健康状况，包括眼部炎症（葡萄膜炎）。当葡萄膜炎不受控制时，会导致眼睛疼痛，发红和视力模糊。严重时，可能会导致永久失明。
Some treatments – includingsteroidsand甲氨蝶呤- 可以提供帮助，但它们并不适合所有人。即使接受治疗，有些人仍然有失去视线的风险。
At Versus Arthritis, we refuse to accept the impact that JIA and uveitis have on young people’s lives, and we want to ensure that they get the most effective treatment possible.
That’s why, in 2011, we funded the SYCAMORE study to find a better option.
What research did we fund, and what did it reveal?
我们与美国国家卫生研究所（NIHR）共同资助的无组织研究试图了解一种称为Adalimumab的药物是否与甲氨蝶呤一起服用，可以帮助患有JIA和葡萄膜炎的儿童。
adalimumab是一种生物疗法 - 一种由人体产生的蛋白质或其他物质制成的一种治疗方法。它与称为肿瘤坏死因子（TNF）的人体中的蛋白质结合，该因子会引起炎症。通过与TNF结合，阿达木单抗阻止炎症并缓解关节炎和葡萄膜炎的症状。
How does anti-TNF work?
几十年来，医疗保健专业人员已经使用Adalimumab来治疗患有炎症状况的成年人，但是有很少的证据表明它是否可以帮助年轻人。Sycamore - 由Athimalaipet Ramanan教授和迈克尔·贝雷斯福（Michael Beresford）在大学医院布里斯托尔NHS基金会信托基金会指挥 - 试图找出是否也可以帮助孩子。
在这项研究中,医生给了年轻人lready taking methotrexate additional treatment with adalimumab. Then, they monitored these children for 18 months. Importantly, the team designed the trial to allow children whose symptoms did not improve to stop and to move on to different treatments.
审判是一个重大成功。Sycamore表明，与甲氨蝶呤结合使用Adalimutab可以有效控制JIA儿童的葡萄膜炎，并有助于防止视力丧失。实际上，早期的结果是如此有希望，以至于研究的独立委员会采取了罕见的步骤来尽早停止试验，以便可以为所有试验参与者提供这种治疗方法并从中受益。
梧桐如何改变卫生专业人员对待年轻人的方式？
由于来自Sycamore的证据，卫生当局更新了英格兰的政策，以确保每个患有JIA和葡萄膜炎的年轻人都可以使用Adalimumab和甲氨蝶呤，这意味着更少的孩子有失去视线的风险。现在，全球其他65个国家都可以使用这种治疗方法。
试验设计还塑造了研究人员进行研究的方式。此后，其他研究人员跟随Ramanan教授和Beresford的领导者在设计试验方面的领导者，如果症状无法改善，人们可以迅速进入其他治疗方法。
Recruiting the number of patients required to answer the research question is often a challenge, particularly in conditions such as JIA where the number of patients is small. We were aware of the importance of this work, and therefore when recruitment was struggling and it looked like the study would not be able to carry on, Versus Arthritis took action and worked closely with the research team to adapt the recruitment process and improve communication between ophthalmology and rheumatology departments, ensuring that the study could continue.
Sycamore还导致了年轻人如何获得护理的其他重要改进 - 近年来，在同一诊所中看到了更多的风湿病学和眼科服务，因此孩子们可以在同一地方看到他们的健康团队。
莉莉的故事
Many children and young people treated withadalimumaband甲氨蝶呤have been able to live fuller lives and experience fewer symptoms. And behind the trial’s success are young people who volunteered to take part. One of those young people is Lily, who was diagnosed with JIA when she was just three years old.
Lily’s JIA meant that her joints were too sore and swollen for her to walk to school with her friends, and daily tasks were painful and difficult.
She also had uveitis, and despite her doctors’ best efforts, available treatments weren’t working well enough. According to Lily’s mum, Jane, the family was losing hope – Lily’s options were running out, and she was at risk of permanent damage to her vision.
然后，当莉莉五岁的时候，她参加了《无组织研究》，简（Jane）将其描述为莉莉（Lily）的最后希望。允许她的女儿接受尚未证明工作的药物治疗是一个艰难的决定，但简知道这是莉莉最好的机会。幸福的是，莉莉（Lily）就像参加梧桐（Sycamore）的许多孩子一样，对治疗做出了很好的反应。自从审判结束以来，治疗组合使她的状况蓬勃发展。
莉莉的日子现在充满了舞蹈，体操，与家人共度时光，并过着正常，快乐和活跃的生活。根据简的说法，莉莉的生活非常忙于她的治疗使她成为可能的所有活动，以至于她“没有时间患有关节炎”。