哪种药?

AXE09
AXE09 成员帖子:11

你好

我最近被诊断出患有RA,这有点震惊。适合且非常活跃的男性。

我尚未开始使用药物(因为我可能否认可能是否认的),但尚未确定是每天用笔注射或口服磺胺丙嗪服用甲氨蝶呤。我得到了选择!

根据我的收集,SFZ在MTX上的有效性不佳,但严重的副作用可能会更少?

任何建议将不胜感激。

注释

  • Jeddison1985
    Jeddison1985 主持人帖子:174

    你好@axe09首先,让我欢迎您参加论坛,希望您能找到来自我们美好社区的信息和支持。

    从您的帖子中,我可以看到您最近被诊断出患有RA,不确定您应该尝试哪种药物。从您过去提到的两种药物的个人经验中,我都可以告诉您,每个人的反应都是个人的。

    该网站上充满了信息,我想向您提供一些信息,这些信息可以帮助甲氨蝶呤和磺胺丙嗪。

    这也是甲氨蝶呤的线程,人们以前分享了他们的经验。

    <\/img> x","bodyRaw":"Hey im going on methotrexate and i was wondering do you take folic acid the day before or the day after you have taken the methotrexate. :smile: x","format":"bbcode","dateInserted":"2011-02-22T14:51:46+00:00","insertUser":{"userID":18423,"name":"loopylou94","url":"https:\/\/community.versusarthritis.org\/profile\/loopylou94","photoUrl":"https:\/\/wa.vanillicon.com\/v2\/a180e92fa9b59b5792fb5d2bddfc4ea7.svg","dateLastActive":"2012-09-18T09:50:22+00:00","banned":0,"punished":0,"private":false},"displayOptions":{"showUserLabel":false,"showCompactUserInfo":true,"showDiscussionLink":false,"showPostLink":false,"showCategoryLink":false,"renderFullContent":false,"expandByDefault":false},"url":"https:\/\/community.versusarthritis.org\/discussion\/comment\/314878#Comment_314878","embedType":"quote"}"> https://community.versusurthritis.org/discussion/comment/314878#comment_314878

    和类似的磺胺丙嗪。

    请随时搜索与其他经验相似的其他人的论坛,我相信我们的一些社区将能够帮助提供一些有用的建议。

    保重,希望您能尽快得到一些缓解和答案。

    谢谢

  • Frogmorton
    Frogmorton 成员帖子:27,024
    编辑16. 2021年11月16日,05:55

    你好@axe09

    您已经很好地总结了两个选项!我想这是个人选择的问题。

    反复试验是问题的真实性以及您自己的个人疾病的积极性。许多人根本没有经历许多副作用,而有些人则在适应系统中的“新事物”时会遇到很多副作用。

    无论哪种情况,您都会受到密切监视,尤其是在开始时,以确保您的身体应对它们。

    我个人会咬子弹并做出决定。请让我们知道您选择的!

    小心

  • AXE09
    AXE09 成员帖子:11

    谢谢@frogmorton@jeddison1985有关信息,这非常有帮助。

    我必须补充说,我在栅栏上的唯一原因是我的诊断发生了非常意外的事情。

    诊断之前没有真正的关节痛。

    我的第一种AZ疫苗使我的对面(肘)发炎和锁定。我几乎无法举起手臂)。我看不到医生面对面,但被告知可能是网球肘,我应该做一些手/手腕锻炼。

    几个月后,情况开始改善,我能够完成以前可以做的大部分事情(除了训练外,担心我可能造成什么伤害!)。长话短说,我接受了第二次AZ疫苗,在12小时内,我在A&E住院了8天。我的肘部严重发炎。我无法再次移动它。我是IV的抗生素和液体。CRP和RF令人担忧,但关节在MRI和X射线上看起来都不错。CRP现在为4.2,但RF和Anti-CCP是阳性的。

    根据骨科治疗后,我经过了疫苗的细菌感染,这些骨科在感染后将我转移到了风湿病。自从我上次AZ疫苗和几周前的超声波检查似乎正在改善以来的5个月,表现出炎症。我能够继续做大多数事情,园艺,繁重的工作,所以我不确定该怎么做。诊断后的14周后,我应该疼痛还是正常感觉很好?

    因此,立即开始使用药物的原因有点犹豫,但是如果我要继续(我相信我会的),我会选择SFZ。如果我的症状随着时间的流逝而继续改善,您仍然建议仅根据血液读数服用药物吗?我了解这确实是专业人士的问题,但只是试图根据过去的经验来对此有所了解。我的顾问正在推动我带他们去,我知道她只是在试图提供帮助,但我从未经历过这样的事情,从来没有经历过,发现很难理解RA诊断的所有变量。我不想对肘部造成任何不可逆转的损害(因为这非常有用!!)

    对长篇文章表示歉意,如果我将其发布在错误的地方

  • 詹姆
    詹姆 成员帖子:6

    有趣的是了解您的经历 - 我的诊断是在10月开始的,因为膝盖突然突然肿胀(骑自行车假期后几天,但后来有些人对Covid进行了阳性,在第二次辉瑞jab之后的一个月),没有其他人,也没有其他测试症状。如果类固醇注射/液体排干,似乎使它们平静下来,但是现在几天后,流感戳刺就无法在不使用手的情况下从椅子上站起来,然后等待风湿病护士的回电。像你一样,通常适合和活跃

  • Frogmorton
    Frogmorton 成员帖子:27,024

    啊!我现在看到你的担忧@axe09

    RA(和大多数炎症性关节炎)的事情是,它们似乎已经消失了,而且几个月来的人甚至几年都很好。认为这一切都很容易,但这是您可能会造成的长期伤害的想法。正如您所说,肘部非常有用!

    目前,CRP(炎症标记)已经下降,但是如果您再次发作,它将恢复。在超声波上仍然可见炎症。嗯。...您的顾问不希望您可能会对关节长期损害。

    她希望做出多快的决定?她很乐意推迟到您下一次评论吗?。听起来好像您已经决定在那儿沿着药物路线时尝试硫。如果有帮助的话,绝对有一个人仅控制硫的疾病。

    您无需为长期帖子道歉,这很有用,并且根本没有在错误的位置发布。

    @JenhB我很高兴您从风湿病学中回电,并且仍在受到监控。可能是您的疫苗接种是连接的,但也许不是巧合。我希望您和OP在“某个地方”中被指出,以防其更为广泛。希望您能尽快为您改善,您得到一些答案(((((((((),((((),您)

  • AXE09
    AXE09 成员帖子:11
    Interesting to read about your experience - my diagnosis happened start of October as knees became very swollen suddenly end of August (a few days after a cycling holiday, but some people subsequently tested positive for Covid and a month after second Pfizer jab) and no other symptoms. Had steroid injection\/fluid drained which seemed to calm them down but now a few days after having a flu jab can't stand up from a chair without using hands and so awaiting a call back from the rheumatology nurse. Like you, normally fit and active<\/p>","bodyRaw":"[{\"insert\":\"Interesting to read about your experience - my diagnosis happened start of October as knees became very swollen suddenly end of August (a few days after a cycling holiday, but some people subsequently tested positive for Covid and a month after second Pfizer jab) and no other symptoms. Had steroid injection\\\/fluid drained which seemed to calm them down but now a few days after having a flu jab can't stand up from a chair without using hands and so awaiting a call back from the rheumatology nurse. Like you, normally fit and active \\n\"}]","format":"rich","dateInserted":"2021-11-16T21:46:30+00:00","insertUser":{"userID":118878,"name":"JenHB","url":"https:\/\/community.versusarthritis.org\/profile\/JenHB","photoUrl":"https:\/\/w6.vanillicon.com\/v2\/65900b3841c155555985759782912ee1.svg","dateLastActive":"2021-12-13T19:44:39+00:00","banned":0,"punished":0,"private":false},"displayOptions":{"showUserLabel":false,"showCompactUserInfo":true,"showDiscussionLink":false,"showPostLink":false,"showCategoryLink":false,"renderFullContent":false,"expandByDefault":false},"url":"https:\/\/community.versusarthritis.org\/discussion\/comment\/687172#Comment_687172","embedType":"quote"}"> https://community.versusarthritis.org/discussion/comment/687172#comment_687172

    这不是一个困难的事。RA处于休眠状态,疫苗将其触发为爆炸,因此它已将其提升到可能是一件好事。或者,疫苗已经引起了疫苗(我敢说!),但我想我们永远不会知道答案。

    我们不知道,如果疫苗造成了疫苗,是否将是永久性的,或者症状会及时消退?无论这些问题的答案如何,我们都应该尝试控制它,以防万一它是我们化妆的永久特征

    我很想知道您的风湿病学护士对此有何看法,以及您的血液测试是否对RA呈阳性。

  • AXE09
    AXE09 成员帖子:11
    Aha! I see your concerns now @Axe09<\/a> <\/p>

    Thing with RA (and most inflammatory Arthritides) is they can be like that appear to be gone and all is well for months some people even years. It's tempting to think it's all over, but it's that thought of long term damage you might be doing. As you say an elbow is very useful to have!<\/p>

    CRP (inflammatory markers) is down at the moment, but if you flare again it will go back up. Inflammation is still visible on ultrasound. Hmmm....your consultant won't want you to risk long-term damage to your joints.<\/p>

    How quickly does she want a decision? Is she happy to delay until your next review? . It sounds as though you have made a decision there to try Sulf as and when you go down the meds route. If it helps there have absolutely been people here whose disease is under control on Sulf alone.<\/p>

    You do not need to apologise for the long post it was useful and not posted in the wrong place at all.<\/p>

    @JenHB<\/a> I am glad you are getting a called back from Rheumatology and are still being monitored. It could be that your vaccinations are linked, but maybe not it could be a coincidence. I hope yours and OP's have been noted 'somewhere' in case it is more widely significant. I hope things improve for you soon and you get some answers ((()))<\/p>","bodyRaw":"[{\"insert\":\"Aha! I see your concerns now \"},{\"insert\":{\"mention\":{\"name\":\"Axe09\",\"userID\":119206}}},{\"insert\":\" \\nThing with RA (and most inflammatory Arthritides) is they can be like that appear to be gone and all is well for months some people even years. It's tempting to think it's all over, but it's that thought of long term damage you might be doing. As you say an elbow is very useful to have!\\nCRP (inflammatory markers) is down at the moment, but if you flare again it will go back up. Inflammation is still visible on ultrasound. Hmmm....your consultant won't want you to risk long-term damage to your joints.\\nHow quickly does she want a decision? Is she happy to delay until your next review? . It sounds as though you have made a decision there to try Sulf as and when you go down the meds route. If it helps there have absolutely been people here whose disease is under control on Sulf alone.\\nYou do not need to apologise for the long post it was useful and not posted in the wrong place at all.\\n\"},{\"insert\":{\"mention\":{\"name\":\"JenHB\",\"userID\":118878}}},{\"insert\":\" I am glad you are getting a called back from Rheumatology and are still being monitored. It could be that your vaccinations are linked, but maybe not it could be a coincidence. I hope yours and OP's have been noted 'somewhere' in case it is more widely significant. I hope things improve for you soon and you get some answers ((()))\\n\\n\"}]","format":"rich","dateInserted":"2021-11-17T07:24:24+00:00","insertUser":{"userID":10897,"name":"frogmorton","url":"https:\/\/community.versusarthritis.org\/profile\/frogmorton","photoUrl":"https:\/\/us.v-cdn.net\/6031919\/uploads\/userpics\/658\/nR70FPCVTDA14.jpg","dateLastActive":"2022-01-22T06:30:39+00:00","banned":0,"punished":0,"private":false},"displayOptions":{"showUserLabel":false,"showCompactUserInfo":true,"showDiscussionLink":false,"showPostLink":false,"showCategoryLink":false,"renderFullContent":false,"expandByDefault":false},"url":"https:\/\/community.versusarthritis.org\/discussion\/comment\/687177#Comment_687177","embedType":"quote"}"> https://community.versusarthritis.org/discussion/comment/687177#Comment_687177

    嗨,托尼

    您会说我的症状(住院)是典型的坏爆发吗?这发生了什么?我忘了补充说我的BP非常低,温度很高。在检查了我的血液检查结果后,我非常差,并认为最糟糕的情况会发生,是的,它几乎使我脱颖而出!我的白细胞计数很低。一个月后,除抗CCP外,我所有的血液结果都回到了正常状态,所以这有点奇怪。我的全科医生建议我在黄牌系统上向MHRA注册它,以防它是AZ疫苗的副作用。我有兴趣知道是否有许多其他人也有类似的问题。

    CRP在反CCP读数时波动的RA是否正常?反CCP阅读是否有可能波动,或者一旦积极就会保持积极?

    我必须在12月7日见我的顾问。下一个约会的目的是确定我对哪种药物感到满意并开始服用它。每当我看到她时,她都说我总是有很多问题,感觉就像是医疗评估。

  • Frogmorton
    Frogmorton 成员帖子:27,024

    好吧,这对你来说是新的@axe09因此,目前您将有很多事情要问您的风湿病学家。

    CRP肯定会波动,我记得当我最小的白血病时,她的血液每天都做完了,她的炎症/感染标记以前甚至警告我们,她会严重生病。在她的情况下,在我们的情况下,可能有爆发。

    没有人提到反CCP一旦再次积极,他们似乎只是看着CRP和考试以评估疾病活动。一定要找出您可以非常有趣的东西!

    并不是每个人最终都住院,但当然有些人这样做。就我而言,我觉得自己有一天醒来了,“陷入困境”根本无法拉直我的腿。回顾过去,有短期的肿胀和高(ISH)温度的线索。耀斑差异很大,但是您所描述的大多数不是毫不典型的,我想像的高温非常疲倦吗?肿胀和疼痛,关节非常僵硬。我的第一次耀斑持续了大约6周,并逐渐减少。从那时起,我当然就一直在服药,耀斑较少,而且持续时间似乎更短。

    绝对应该在黄牌上报告有关AZ疫苗接种100%的黄牌,他们需要此类信息,他们将决定是否相关。

    在12月7日祝你好运确保您让我们知道您的决定。

  • CCM
    CCM 成员帖子:54

    40年前,当我得到RA诊断时,我是一个健康而活跃的男性。现在不太活跃,但谁在73岁时就不那么活跃了。我的意思是会有起伏,但生活仍然可以享受。喜欢您可以做的事情,但不要后悔您无法管理的事情。

    我一直在药丸和注射和磺胺氨酸盐上使用甲氨蝶呤。我更喜欢磺胺丙嗪,在我的情况下,它与羟氯喹结合使用。

    祝你好运

    CCM

  • AXE09
    AXE09 成员帖子:11
    40 years ago I was a fit and active male when I was given my RA diagnosis. Less active now, but who isn't at 73. My point is that there will be ups and downs, but life is still there to be enjoyed. Relish the things you can do, but do not regret the things you can no longer manage.<\/p>

    I have been on Methotrexate by pill and injection and Sulfasaline. I prefer the Sulfasalazine, which in my case is combined with Hydroxychloroquine. <\/p>

    Good luck<\/p>

    CCM<\/p>","bodyRaw":"[{\"insert\":\"40 years ago I was a fit and active male when I was given my RA diagnosis. Less active now, but who isn't at 73. My point is that there will be ups and downs, but life is still there to be enjoyed. Relish the things you can do, but do not regret the things you can no longer manage.\\nI have been on Methotrexate by pill and injection and Sulfasaline. I prefer the Sulfasalazine, which in my case is combined with Hydroxychloroquine. \\nGood luck\\nCCM\\n\"}]","format":"rich","dateInserted":"2021-11-18T11:07:19+00:00","insertUser":{"userID":114714,"name":"CCM","url":"https:\/\/community.versusarthritis.org\/profile\/CCM","photoUrl":"https:\/\/us.v-cdn.net\/6031919\/uploads\/userpics\/H7BFGI11GBKF\/n0VD775RPLGZ8.jpg","dateLastActive":"2021-12-02T11:17:32+00:00","banned":0,"punished":0,"private":false},"displayOptions":{"showUserLabel":false,"showCompactUserInfo":true,"showDiscussionLink":false,"showPostLink":false,"showCategoryLink":false,"renderFullContent":false,"expandByDefault":false},"url":"https:\/\/community.versusarthritis.org\/discussion\/comment\/687225#Comment_687225","embedType":"quote"}"> https://community.versusarthritis.org/discussion/comment/687225#comment_687225

    很好的建议,谢谢!

  • 肢瘤炎
    肢瘤炎 成员帖子:168

    @axe09@CCMI am also recently Dx’d, in October, but doc suspected it in july, and thought the trigger might have been excessive excercise walking in Sept 2020, resulting in unbearably painful feet which resolved, but distance walked steadily declined, until one morning in july I woke with painful stiff hands and feet, which did resolve, and i stayed in denial, esp after a hospital doc told me i didn’t have it after pushing and pulling my hands, even though i explained i struggled with taps. In denial I stayed until my right index finger tendon was on fire and finger unmovable. Then saw private rheumy in Oct and bloods came high +ve. He wanted me to take mtx immediately but i was hesitant as these drugs need careful monitoring and i had did’t have funds for a follow up. I am hoping the serology will get me referred to an nhs rheumatology programme soon. I took the hydroxy prescription though.

  • 詹姆
    詹姆 成员帖子:6

    回答@axe09- 9月,我的血液显示出高的类风湿因素,因此我的转诊!她认为流感刺刀可能引起了一些肌肉僵硬,因为我膝盖上最多注意到,由于我的肌肉张力大幅损失,而且我也没有明显的肿胀或疼痛。我有电话约会开始,只是为了检查情况如何。

  • AXE09
    AXE09 成员帖子:11

    @JenhB

    我想他们不能太担心他们是否离开一月?我希望一个好兆头

    我今天下午要预约药物。尽管我的诊断以及如何发生,但仍然担心将它们带来太多变量。

    让我们了解您的进度。

  • @JenhB嗨,您知道您的ACCP级别是多少?

    请不要仅仅因为您的全科医生具有自由放任的态度,这意味着可以或不认真。这只是意味着您的全科医生不知道NHS对此的最佳实践指南,“努力迅速”并将其视为紧急,因为限制损害的最佳前景是在扩散之前提前解决它,并在不可逆的伤害下变得很重要。我最终向我的NHS诊所教育了OA&RA之间的差异,并从患者视频中转发了一个链接,可以准确地描述了差异,并且缺乏对RA和紧急治疗需求的认识。

    他们很亲切,可以承认手术中的所有临床医生都会受益于观看。对我来说太晚了,因为我在7月份报告了我的症状,而且他们没有注意到,直到我最终消耗了所有的积蓄,试图看到一个私人风湿病,他迅速诊断出我接受了ACCP,RF和ANA测试的诊断我有一个非常激进的形式。

    我将推动从GP定期进行以下测试:

    ACCP

    RF

    安娜

    C-RP

    ESR

    您可能想对此进行一些研究,但最重要的是,您的全科医生认真对待它,因为它是。GO越早解决,您的前景就越好。

  • 好奇的人
    好奇的人 成员帖子:15
    编辑14. 2021年12月21日:20

    你好@axe09,长期发布,我希望这有帮助...

    我的经历与您的经历相似!我三月份的AZ疫苗接种了,两天后,我发现自己无法拉直肘部。不久之后疼痛随之而来。接下来,我下巴疼痛,它变得不对。然后在我的臀部和下脊柱上疼痛,然后膝盖和脚踝肿胀。我的诊断目前是银屑病关节炎,有一个问号。还提到了强直性脊柱炎,但是每个人都有一些困惑,因此他们无法确切地决定它是什么样的关节炎。

    我是女性,30岁(现在31岁)在此之前没有症状,进行了很多症状,从事身体工作,没有超重,没有关节炎的家族史。大约6年前,我患有极度温和的牛皮癣。

    医生测试了我的不发炎标记,并订购了我的肘部X射线,并告诉我我没有关节炎。(CRP 14,ESR 26,没有X射线关节损坏的迹象)。我设法进行了生理转诊,生理学将我转介给风湿病学家,他们下令进行超声波和MRI。它们都表现出非常明显的炎症,随后我被诊断出来,并开了eToricoxib和甲氨蝶呤。

    因为我确定所有这些都是由疫苗引起/触发的,所以我也很害怕开始药物。当我表达自己的信念,即疫苗引起的这种情况已经侵蚀了我对医疗保健系统的信任,直到几乎不存在的地步。

    您对疫苗的担忧是否受到任何人的认真采用?我一直被告知有“没有证据”疫苗可能引起这一点,这只是“巧合”。每天,我都会听到或阅读一些使我更确定疫苗引起或触发的东西。


    无论如何,我得到了MTX或SSZ的选择,并且对甲氨蝶呤更加害怕,因此将选择磺胺丙嗪,但是在阅读了各种经验并权衡危险,有效性,副作用等之后,我决定让甲氨蝶呤尝试一下。我选择注射,因为我读到某些副作用的可能性较小。我在MTX上一个月后到目前为止的经验:

    注射#1(10mg)的第二天:我听说过的“宿醉”。头痛,非常恶心,极度疲劳。第二天我还好。

    注射后的第二天(10mg):罚款

    注射#3(15mg)的第二天:与初次剂量之后相同的宿醉

    注射#4(15mg)后的第二天:很好(即使在几天前狂欢之后!)

    到目前为止,我只有一次血液检查,但结果没有任何问题。我本周还有另一个。

    自从我开始MTX以来,我一直在连续一段时间,风湿病学家似乎并不关心,但这是血腥的烦人(请赦免双关语。)这是我到目前为止唯一注意到的唯一连续的副作用。


    我很遗憾得知您发生了什么事。如此震惊,如此奇怪的经历突然被扔进了这一点,没有任何警告。我也是新手,绝对无法提供专业知识,但如果有帮助,请随时给我发消息!

  • Frogmorton
    Frogmorton 成员帖子:27,024

    签出那个时期@axe09为什么没有停止?

    这需要确定。

    小心

  • AXE09
    AXE09 成员帖子:11

    我读到MTX会影响您的卵巢吗?这不是我的领域,但我会说肯定需要尽快与顾问讨论!

谁在线上

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